CRISPR

Amy Dockser Marcus of The Wall Street Journal writes about the growing interest in using CRISPR as a diagnostic tool, which led to a collaboration between MIT Professors James Collins and Feng Zhang. The result is Sherlock, a diagnostic platform that can identify viruses “based on extremely low amounts of RNA in blood and urine samples,” explains Dockser Marcus.

The Economist writes about new research from Prof. Chris Voigt, in which “he and his colleagues demonstrate how to control customised cells with coloured light.”

TIME reporter Alice Park writes that MIT researchers have modified the CRISPR gene-editing system so that it could be used to diagnose disease. Park explains that the researchers, “used CRISPR to recognize specific substances that bacteria and viruses make. Picking up even the slightest whisper of these products can alert doctors that an infection is active.”

MIT researchers have developed a new technique that uses the CRISPR gene-editing system to diagnose diseases, reports Joel Achenbach for The Washington Post. Achenbach explains that the tool could potentially be used to “detect not only viral and bacterial diseases but also potentially for finding cancer-causing mutations.”

Boston Herald reporter Jordan Graham writes that a committee co-chaired by Prof. Richard Hynes has made a series of recommendations for the use of gene editing in humans. Graham explains that the committee recommended “leaving the door open to altering the human genome in ways that would affect the descendants of patients with hereditary diseases and disabilities.”

A committee co-chaired by Prof. Richard Hynes has presented a set of guidelines for using the CRISPR gene-editing tool in humans, reports Lauran Neergaard for the AP. Neergaard writes that Hynes noted, “safety is one reason for caution, as scientists will have to learn whether editing one gene has unwanted downstream effects.”

Washington Post reporter Joel Achenbach writes that a committee co-chaired by Prof. Richard Hynes has presented a series of guidelines for applying CRISPR gene editing in humans. “We say proceed with all due caution, but we don’t prohibit germline, after considerable discussion and debate,” says Hynes. “We’re talking only about fixing diseases.”

In this piece for The New Yorker, Michael Specter writes about Prof. Kevin Esvelt’s idea to use gene-editing technology to eradicate Lyme disease. “This is an ecological problem,” Esvelt explains. “And we want to enact an ecological solution so that we break the transmission cycle that keeps ticks in the environment infected with these pathogens.”

Prof. Kevin Esvelt is taking his genetically modified mice proposal for fighting Lyme disease to Martha’s Vineyard, says Carey Goldberg of WBUR. “Everyone would agree we should decide this in New England town hall debate at the local level, rather than handing it over to scientists like me to make unilateral decisions. I’m not for that,” says Prof. Esvelt

MIT researchers have discovered that a bacterium found in the human mouth can be used to form a new CRISPR gene-editing system that can target RNA, reports Carl Zimmer for The New York Times. The development “may open up a new front in gene engineering, gaining the ability to precisely adjust the proteins in cells, for instance, or to target cancer cells." 

Michael Le Page writes for New Scientist that MIT researchers have developed a technique that allows cells to log their activities using the CRISPR gene-editing system. Le Page explains that “such CRISPR-based logging could have a huge range of uses, from smart cells that monitor our health from within, to helping us understand exactly how our bodies develop.”

Prof. Feng Zhang has been named a recipient of the 2016 Canada Gairdner International Award for his work on the development of the CRISPR gene-editing system, reports CBC News. CRISPR "may prove to be a ‘powerful therapeutic’ for treating human diseases by editing out harmful genetic mutations.”

Globe and Mail reporter Ivan Semeniuk spotlights Prof. Feng Zhang and his role in developing the CRISPR-Cas9 gene-editing system, for which he was honored as a recipient of the 2016 Canada Gairdner International award. “CRISPR genome editing technology is a really powerful platform,” says Zhang. “It think it will advance both our ability to understand disease and to develop treatments.”

In an article for The Boston Globe’s special section about the 2015 Bostonians of the Year, Sharon Begley writes about the work of Prof. Feng Zhang. Begley writes that Zhang, "is one of the world’s most creative and influential biological engineers, able to see possibilities where others don’t.”

Huffington Post reporter Lila Shapiro speaks with Robert Desimone, director of the McGovern Institute, about the use of the CRISPR gene-editing technique to treat neurological diseases. “CRISPR’s impact is potentially across the board,” says Desimone. “It went from nothing just a few years ago to being a tool that’s in everyone’s toolbox.”